Medical Professionals: Technology
Closure Medical has earned its reputation as a world-class
developer of medical grade biomaterials because of the highly
innovative products and devices we have provided for physicians
and consumers worldwide. Our success is based on our unprecedented
depth of understanding in polymer biochemistry.
A critical component in Closure Medical’s innovative
medical adhesive devices is our ground-breaking technology
leadership in medical grade, cyanoacrylate-based biomaterials.
- 2-Octyl Cyanoacrylates
First patented in 1949, cyanoacrylates are synthetic adhesive
molecules that when heated become a monomer. Chemists can
create compounds with different molecular chain lengths by
altering the alkoxycarbonyl group to the molecule. The result
is a special type of monomer which reacts to water or bases
with an exothermic hydroxylation that polymerizes the compound.
In medical applications, the monomer material polymerizes
upon contact with the human body, forming a strong, flexible
Cyanoacrylate derivatives can be roughly divided into “short-chain”
and “long-chain” groups. These derivatives have
varying properties, with shorter-chain derivates more histotoxic
than the stronger longer-chain derivatives.
The main types of cyanoacrylates are ethyl cyanoacrylates,
butyl cyanoacrylates, and 2-octyl cyanoacrylates. These adhesives
have found a broad range of applications within and outside
of medical use.
Closure Medical develops and manufactures a proprietary,
highly purified, uniquely innovative, powerfully strong and
biocompatible type of 2-octyl cyanoacrylate for medical professional,
consumer and veterinary use.
The compound 2-octyl cyanoacrylate is a long carbon chain
cyanoacrylate derivative. There are several different types
of compounds that can properly be called 2-octyl cyanoacrylate,
including those that contain four carbons (shorter carbon
chain). In general, long carbon chain cyanoacrylates are stronger,
more pliable, and less histotoxic than shorter carbon chain
Closure Medical develops and manufactures a proprietary 2-octyl
cyanoacrylate compound with a long carbon chain (eight carbons)
to such rigorous standards of purity that the substance is
biocompatible while retaining its excellent bonding strength.
In fact, Closure Medical is the only company to have received
approval from the FDA to market its 2-octyl cyanoacrylate
based products commercially.
In addition to their benefits as safe, effective, flexible
and tenacious adhesive devices for topical wound closure,
products using Closure Medical’s technology have been
shown to act as a microbial barrier, keeping bacteria out
of topical wounds.