CONTACTS AT THE COMPANY AT THE FINANCIAL RELATIONS BOARD
Robert V. Toni, President & CEO
Benny Ward, CFO
CLOSURE Medical Corporation
(919) 876-7800
For General Info: Paula Schwartz (212) 661-8030
For Analyst Info: Julie Tu (212) 661-8030
For Media Info: Judith Sylk-Siegel (212) 661-8030

FOR IMMEDIATE RELEASE: April 17, 2001

CLOSURE MEDICAL TO WEBCAST FIRST QUARTER 2001 CONFERENCE CALL

Raleigh, NC, April 17, 2001 -- CLOSURE Medical Corporation (Nasdaq: CLSR), a medical tissue adhesive products company, today announced that it intends to release, on Tuesday, April 24, 2001, financial results for the first quarter ended March 31, 2001. In conjunction with this release CLOSURE will host a conference call that will be broadcast simultaneously live over the Internet.

Individuals wishing to participate on the webcast, to be held at 4:30 PM EST on Tuesday, April 24, 2001, can access the event at http://www.vcall.com. Please allow extra time prior to the call to download the streaming media software required for listening to the Internet broadcast. The online archive of the broadcast will be available within 2 hours of the live call and will be available for replay for 90 days.

CLOSURE Medical Corporation, headquartered in Raleigh, North Carolina, develops, manufactures, and commercializes medical tissue adhesive products based on its proprietary cyanoacrylate technology. CLOSURE's nonabsorbable tissue adhesive products may be used to replace sutures and staples for certain topical wound closure applications, while its internal tissue adhesive products can potentially be used for internal wound closure and management. Currently marketed nonabsorbable tissue adhesive products include: DERMABONDâ Topical Skin Adhesive, which is used to replace sutures and staples for closure of certain lacerations and incisions; SOOTHE-N-SEAL™ canker sore relief, an over-the-counter product to treat oral ulcers and mouth sores; and NEXABANDâ topical adhesives used in veterinary wound closure and management. The Company's LIQUIDERM™ liquid adhesive bandage has been approved by the FDA for the over-the-counter adhesive bandage market.

DERMABOND® adhesive is a registered trademark of Ethicon, Inc.; SOOTHE-N-SEAL™ canker sore relief is a licensed trademark of Colgate Oral Pharmaceuticals, Inc.; LIQUIDERM™ adhesive is a trademark of CLOSURE Medical Corporation; and NEXABAND® adhesive is a registered trademark of CLOSURE Medical Corporation.To receive CLOSURE's latest news release and other corporate documents via fax, at no cost, call 1-800-PRO-INFO, use the Company's symbol CLSR. Or visit the Financial Relations Board's website at www.frbinc.com.

This release contains certain forward-looking statements which involve known and unknown risks, delays, uncertainties or other factors not under the Company's control which may cause actual results, performance or achievements of the Company to be materially different from the results, performance, or other expectations implied by these forward-looking statements. These factors include, but are not limited to the early stage of commercialization of the Company products; the progress of its research and development programs for future products; the need for regulatory approval and effects of governmental regulation; technological uncertainties; the satisfactory conclusion of negotiations with, and dependence on marketing partners, and dependence on patents and trade secrets, as well as those detailed in the Company's Annual Report on Form 10-K for the year ended December 31, 2000 filed with the Securities and Exchange Commission.